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BIOLOGY AND BIOMEDICAL SCIENCES (L41)  (Dept. Info)Arts & Sciences  (Policies)

L41 BIOL 5394Introduction to Metagenomics: The Study of Microbial Ecosystems3.0 Units
Description:This course introduces students to key questions, approaches, and computational tools used to study the properties of microbial communities in their various habitats. Complex microbial ecosystems are found in a variety of terrestrial and oceanic environments as well as in the various body habitats of metazoan species including humans. These ecosystems, which are composed largely of microbial species that have never been cultured in a lab, are laboratories for the study of genome evolution (eco-genomics), ecological principles, and myriad biotransformations. In particular, many animals, including ourselves, have evolved to live with and benefit from the commensal microbial communities in their GI tracts. The study of microbial ecosystems gives rise to the field of metagenomics - the acquisition, identification, and functional and evolutionary analysis of the combined genomic sequences of a diverse population of organisms. Metagenomic analyses must contend with many challenges, including a high volume of genomic sequence data, fragmentary and incomplete sequences, and genomic heterogeneity of sampled organisms. To tackle these challenges, we must bring to bear computational tools that apply models of sequence evolution to interpret metagenomic sequence data. These interpretations form a basis for further investigation and hypothesis testing. Course content will include an overview of questions and major results in metagenomic research, along with an introduction to the experimental protocols and computational tools, models, and algorithms of metagenomic analysis. The class will have two 1.5 hour meetings per week for 14 weeks. Enrollment is limited to 25 students. Prerequisites: Graduate standing or permission of instructor. Some basic knowledge of biology is recommended. Students should know or be prepared to learn basic Python scripting to carry out some course assignments.
Attributes:
Instruction Type:Classroom instruction Grade Options:CPA Fees:
Course Type:HomeSame As:N/AFrequency:Every 1 or 2 Years / History
Label

Home/Ident

A course may be either a “Home” course or an “Ident” course.

A “Home” course is a course that is created, maintained and “owned” by one academic department (aka the “Home” department). The “Home” department is primarily responsible for the decision making and logistical support for the course and instructor.

An “Ident” course is the exact same course as the “Home” (i.e. same instructor, same class time, etc), but is simply being offered to students through another department for purposes of registering under a different department and course number.

Students should, whenever possible, register for their courses under the department number toward which they intend to count the course. For example, an AFAS major should register for the course "Africa: Peoples and Cultures" under its Ident number, L90 306B, whereas an Anthropology major should register for the same course under its Home number, L48 306B.

Grade Options
C=Credit (letter grade)
P=Pass/Fail
A=Audit
U=Satisfactory/Unsatisfactory
S=Special Audit
Q=ME Q (Medical School)

Please note: not all grade options assigned to a course are available to all students, based on prime school and/or division. Please contact the student support services area in your school or program with questions.


No section found for SP2023.