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BIOLOGY AND BIOMEDICAL SCIENCES (L41)  (Dept. Info)Arts & Sciences  (Policies)

L41 BIOL 5149High Throughput, High Content, Assay Development, Screening & Target Validation-Principle & PracticeVariable Unit
Description:The objective of our course is to introduce students to the world of automation-based discovery science. We will discuss the power of this approach, its constraints and their practical solutions. Specifically, we will introduce the class to the range of available assay tool kits (detection modalities), and the principles that apply towards assay development, library selection (compound, RNAi) and the translation of benchtop methods to automated platforms. We will also discuss sources of error and statistical tools for analyzing large datasets, the hit validation process and lead optimization. Along the way, we will hear from individual investigators describing their own academic or industry screens and critique the growing literature describing results born from high throughput/high content approaches. We realize that high throughput screening raises philosophical issues such as the merit of discovery science vs. hypothesis-driven research, big science, the role of technology in opening new fields of research, etc. We encourage the students to engage with us in these debates while covering the nuts and bolts of high throughput experiments. Minimum enrollment is 5; those interested should contact the coursemaster before May 2011. Prerequisites: Sound foundation in at least one of: biochemistry, cell biology, developmental biology, microbiology, virology, statistics or computational biology.
Instruction Type:Classroom instruction Grade Options:CA Fees:
Course Type:HomeSame As:N/AFrequency:Annually / History


A course may be either a “Home” course or an “Ident” course.

A “Home” course is a course that is created, maintained and “owned” by one academic department (aka the “Home” department). The “Home” department is primarily responsible for the decision making and logistical support for the course and instructor.

An “Ident” course is the exact same course as the “Home” (i.e. same instructor, same class time, etc), but is simply being offered to students through another department for purposes of registering under a different department and course number.

Students should, whenever possible, register for their courses under the department number toward which they intend to count the course. For example, an AFAS major should register for the course "Africa: Peoples and Cultures" under its Ident number, L90 306B, whereas an Anthropology major should register for the same course under its Home number, L48 306B.

Grade Options
C=Credit (letter grade)
S=Special Audit
Q=ME Q (Medical School)

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No section found for SP2023.